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Normal Tissues

HMGA2

Brain

Cerebrum, grey matter
Cerebrum, white matter
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer, white matter)
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer, white matter) (2)
Cerebellum (white matter)

Endocrine Tissues

Adrenal gland
Adrenal gland
Thyroid gland
Thyroid gland – Most follicular cells show a faint to weak nuclear HMGA2 staining
Thyroid gland
Thyroid gland
Parathyroid gland
Parathyroid gland – Some epithelial cell groups show a moderate to strong nuclear HMGA2 staining
Pituitary gland, anterior lobe
Pituitary gland, posterior lobe
Pituitary gland, posterior lobe – Weak to moderate nuclear HMGA2 staining of pituicytes

Respiratory system

Lung

Proximal digestive tract

Tonsil, surface epithelium
Sublingual gland
Parotid gland

Gastronintestinal tract

Stomach, antrum
Stomach, antrum – Weak to moderate nuclear HMGA2 positivity of a fraction of glandular cells
Stomach, antrum
Stomach, antrum – Weak to moderate nuclear HMGA2 positivity of a fraction of glandular cells. (2)
Stomach, corpus
Stomach, corpus – Weak to moderate nuclear HMGA2 positivity of a fraction of glandular cells
Duodenum, brunner gland
Duodenum, brunner gland – Weak nuclear HMGA2 staining of duodenal crypt cells. Moderate HMGA2 positivity of Brunner glands
Colon descendens, mucosa
Colon descendens, mucosa – Weak nuclear HMGA2 staining of a fraction of epithelial cells

Liver, Gallbladder, Pancreas

Liver
Liver – Weak nuclear HMGA2 staining of a fraction of bile duct epithelial cells
Pancreas
Pancreas – Faint nuclear HMGA2 staining of cells from some small ducts
Pancreas
Pancreas – Weak nuclear HMGA2 staining of a fraction of acinar and ductal (small ducts) cells

Kidney, urinary bladder

Kidney, cortex
Kidney, cortex – Absence of HMGA2 staining in this sample
Kidney, cortex
Kidney, cortex – Moderate nuclear HMGA2 staining of tubular cells in areas of tissue damage
Kidney, medulla
Kidney, medulla – Faint nuclear HMGA2 staining of a fraction of collecting duct cells
Urinary bladder, urothelium
Urinary bladder, urothelium – Few urothelial cells show a weak nuclear HMGA2 positivity

Male tissues

Prostate
Seminal vesicle
Seminal vesicle – Strong nuclear HMGA2 staining of a large fraction of acinar glandular cells
Epididymis
Epididymis – Weak nuclear HMGA2 staining of a fraction of epithelial cells in the cauda
Epididymis
Testis
Testis – Weak to moderate nuclear HMGA2 staining of a spermatocytes and of spermatozoa

Female Tissues

Breast
Uterus, ectocervix
Uterus, endocervix
Uterus, endocervix – Strong nuclear HMGA2 staining of epithelial cells
Uterus, endometrium (proliferation)
Uterus, endometrium (proliferation) – Weak to moderate nuclear HMGA2 staining of a subset of epithelial cells
Uterus, endometrium (pregnancy)
Uterus, endometrium (secretion)
Uterus, myometrium
Fallopian tube, mucosa
Fallopian tube, mucosa – Moderate to strong nuclear HMGA2 staining of a large subset of epithelial cells
Fallopian tube, mucosa
Fallopian tube, mucosa – Strong nuclear HMGA2 staining of most epithelial cells
Ovary, follicular cyst
Ovary, corpus luteum
Placenta (amnion and chorion)
Placenta (amnion and chorion) – Strong nuclear HMGA2 positivity of amnion and stroma cells while chorion cells are negative
Placenta, early
Placenta, early – Strong nuclear HMGA2 staining of stroma cells. Trophoblast cells remain HMGA2 negative
Placenta, mature
Placenta, mature – Some nuclear HMGA2 staining of trophoblast cells in some samples. Stroma cells are HMGA2 negative

Muscle, connective & soft tissue

Skeletal muscle
Skeletal muscle – Weak to moderate HMGA2 staining of some myocytes
Skeletal muscle
Aorta, media
Heart muscle
Urinary bladder, muscular wall
Stomach, muscular wall
Appendix, muscular wall
Colon descendens, muscular wall

Skin

Skin
Skin
Skin, hairfollicel and sebaceous glands

Bone Marrow & lymphoid tissues

Bone marrow
Bone marrow – Moderate nuclear HMGA2 staining of a fraction of cells
Thymus
Spleen
Lymph node
Lymph node (2)
Tonsil