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Cancer Tissues

HMGA2

Endocrine Tissues

Adrenal gland
Adrenal gland – Adrenocortical carcinoma with a weak HMGA2 staining of most tumor cells
Adrenal gland
Adrenal gland – HMGA2 negative pheochromocytoma
Thyroid
Thyroid – Anaplastic carcinoma with strong HMGA2 positivity of tumor cells
Thyroid
Thyroid – Anaplastic carcinoma with strong HMGA2 staining of most tumor cells
Thyroid
Thyroid – Follicular carcinoma with strong HMGA2 staining of all tumor cells
Thyroid
Thyroid – Medullary carcinoma with moderate to strong HMGA2 staining of tumor cells
Thyroid
Thyroid – Papillary carcinoma with strong HMGA2 staining of tumor cells
Parathyroid
Parathyroid – Adenoma with weak to moderate HMGA2 staining of tumor cells

Respiratory system

Lung
Lung – Adenocarcinoma with strong HMGA2 staining of all tumor cells
Lung
Lung – HMGA2 negative malignant mesothelioma
Lung
Lung – Malignant mesothelioma with strong HMGA2 immunostaining of tumor cells
Lung
Lung – Squamous cell carcinoma with a variable (weak – strong) HMGA2 staining of tumor cells

Proximal digestive tract

Oral cavity
Oral cavity – Squamous cell carcinoma with strong HMGA2 staining of tumor cells
Esophagus
Esophagus – Adenocarcinoma with strong HMGA2 positivity of tumor cells
Esophagus
Esophagus – HMGA2 negative squamous cell carcinoma
Esophagus
Esophagus – Squamous cell carcinoma with strong HMGA2 staining of tumor cells
Salivary gland
Salivary gland – HMGA2 negative Warthin tumor
Salivary gland
Salivary gland – Pleomorphic adenoma with strong HMGA2 staining of tumor cells

Gastronintestinal tract

Stomach
Stomach – Gastric adenocarcinoma (intestinal type) with strong HMGA2 staining of tumor cells
Stomach
Stomach – Gastric adenocarcinoma (intestinal type) with weak to moderate HMGA2 staining of most tumor cells
Stomach
Stomach – Gastrointestinal stromal tumor (GIST) showing a moderate to strong HMGA2 staining of tumor cells
Stomach
Stomach – HMGA2 negative gastric adenocarcinoma (diffuse type)
Colon
Colon – Colorectal adenocarcinoma showing a faint HMGA2 positivity a small set of tumor cells
Colon
Colon – Colorectal adenocarcinoma with strong HMGA2 staining of tumor cells
Colon
Colon – Colorectal adenoma (low-grade) with weak to moderate HMGA2 staining of neoplastic cells

Liver, Gallbladder, Pancreas

Liver
Liver – Cholangiocellular carcinoma with strong HMGA2 positivity of tumor cells
Liver
Liver – Hepatocellular carcinoma with exhibiting a strong HMGA2 staining of tumor cells
Liver
Liver – HMGA2 negative cholangiocellular carcinoma
Pancreas
Pancreas – Ductal adenocarcinoma with moderate intensity HMGA2 staining of tumor cells
Pancreas
Pancreas – Ductal adenocarcinoma with strong HMGA2 immunostaining of tumor cells
Pancreas
Pancreas – HMGA2 negative adenocarcinoma of the papilla Vaterii exhibiting a moderate intensity HMGA2 staining of stroma cells
Pancreas
Pancreas – HMGA2 negative neuroendocrine tumor

Kidney, urinary bladder

Kidney
Kidney – HMGA2 negative clear cell carcinoma
Kidney
Kidney – Papillary renal cell carcinoma with strong HMGA2 immunostaining of all tumor cells
Soft tissue
Soft tissue – Rhabdoid tumor with strong HMGA2 positivity of tumor cells
Urinary bladder
Urinary bladder – HMGA2 negative muscle-invasive urothelial carcinoma
Urinary bladder
Urinary bladder – Muscle-invasive urothelial carcinoma (pT2-4) with strong HMGA2 staining of tumor cells
Urinary bladder
Urinary bladder – Sarkomatoid carcinoma with strong HMGA2 positivity of tumor cells
Urinary bladder
Urinary bladder – Sarkomatoid carcinoma with weak to moderate HMGA2 staining of a fraction of tumor cells

Male tissues

Prostate
Prostate – HMGA2 negative adenocarcinoma (Gleason 3+3=6)
Testis
Testis – HMGA2 negative Leydig cell tumor
Testis
Testis – HMGA2 negative seminoma
Testis
Testis – Yolk sack tumor showing strong HMGA2 staining of tumor cells. of tumor cells

Female Tissues

Breast
Breast – HMGA2 negative invasive breast cancer of no special type (NST)
Breast
Breast – HMGA2 negative invasive lobular breast cancer
Uterus, cervix
Uterus, cervix – HMGA2 negative adenocarcinoma
Uterus, cervix
Uterus, cervix – HMGA2 negative squamous cell carcinoma
Ovary
Ovary – Granulosa cell tumor with a moderate intensity HMGA2 staining of tumor cells
Ovary
Ovary – HMGA2 negative serous high-grade carcinoma
Ovary
Ovary – Malignant mixed Mullerian tumor with strong HMGA2 staining of all epithelial and mesenchymal tumor cells
Ovary
Ovary – Serous high-grade carcinoma with a variable (weak – strong) HMGA2 staining of tumor cells
Ovary
Ovary – Serous high-grade carcinoma with strong HMGA2 staining of all tumor cells

Muscle, connective & soft tissue

Penis
Penis – HMGA2 negative squamous cell carcinoma

Skin

Skin
Skin – Merkel cell carcinoma with intense HMGA2 staining of all tumor cells
Anal canal
Anal canal – Squamous cell carcinoma with strong HMGA2 staining of tumor cells

Bone Marrow & lymphoid tissues

Soft tissue
Soft tissue – Chondrosarcoma with strong HMGA2 staining of tumor cells
Thymus
Thymus – Thymoma with weak to moderate HMGA2 positivity of tumor cells
Lymph node
Lymph node – HMGA2 negative B-CLL
Lymph node
Lymph node – HMGA2 negative diffuse large B-cell lymphoma
Lymph node
Lymph node – HMGA2 negative Hodgkin’s lymphoma
Lymph node
Lymph node – Hodgkin’s lymphoma exhibiting a strong HMGA2 staining of tumor cells
Lymph node
Lymph node – Hodgkin’s lymphoma showing a strong HMGA2 staining of tumor cells
Lymph node
Lymph node – Hodgkin’s lymphoma with strong HMGA2 immunostaining of tumor cells