Normal Tissues

Glucocorticoid Receptor

Brain

Cerebrum, grey matter
Cerebrum, grey matter – Moderate GR positivity of neuronal cells
Cerebrum, white matter (2)
Cerebrum, white matter
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer)
Cerebellum (white matter)

Endocrine Tissues

Adrenal gland
Adrenal gland – Moderate to strong GR positivity of medullary cells while adrenocortical cells are largely GR negative
Thyroid gland
Thyroid gland – Moderate to strong GR positivity of follicular epithelial cells
Parathyroid
Parathyroid – Moderate to strong GR positivity of epithelial cells
Pituitary gland, anterior lobe
Pituitary gland, anterior lobe – Moderate to strong GR positivity of epithelial cells
Pituitary gland, posterior lobe
Pituitary gland, posterior lobe – Weak GR positivity of pituicytes

Respiratory system

Lung
Lung – Strong GR positivity of pneumocytes

Proximal digestive tract

Esophagus, squamous epithelium
Esophagus, squamous epithelium – Intense GR staining of squamous epithelial cells. Staining intensity decreases sligthly towards the surface
Tonsil, surface epithelium
Tonsil, surface epithelium – Intense GR positivity of squamous epithelial cells. Staining intensity decreases slightly towards the surface

Gastronintestinal tract

Stomach, antrum
Stomach, antrum – Moderate GR positivity of superficial epithelial cells. Staining is weakest in gastric glands
Stomach, corpus
Stomach, corpus – Moderate GR positivity of superficial epithelial cells. Staining is weakest in gastric glands
Duodenum, Brunner gland
Duodenum, Brunner gland – Moderate GR positivity of Brunner gland cells
Colon descendens, mucosa
Colon descendens, mucosa – Moderate GR positivity of epithelial cells

Liver, Gallbladder, Pancreas

Liver
Liver – Moderate GR positivity of hepatocytes, ductal cells and of lymphocytes
Pancreas
Pancreas – Moderate to strong GR positivity of acinar cells while islet cells show a strong staining

Kidney, urinary bladder

Kidney, cortex
Kidney, cortex – Moderate to strong GR positivity of all epithelial cells
Kidney, medulla
Kidney, medulla – Moderate to strong GR positivity of all epithelial cells
Kidney, pelvis, urothelium
Kidney, pelvis, urothelium – Weak to moderate GR positivity of the basal and suprabasal cell layers of the urohelium. Superficial cell layers are largely GR negative
Urinary bladder, urothelium
Urinary bladder, urothelium – Weak to moderate GR positivity of the basal and suprabasal cell layers of the urohelium. Superficial cell layers are largely GR negative

Male tissues

Prostate
Prostate – Moderate to strong GR positivity of epithelial cells
Seminal vesicle
Seminal vesicle – Moderate to strong GR positivity of all epithelial cells
Epididymis
Epididymis – Moderate to strong GR positivity of all epithelial cells of the caput epididymis
Testis
Testis – Intense GR positivity of Sertoli and Leydig cells. Cells of the spermatogenesis do not show significant GR staining

Female Tissues

Breast
Breast – Moderate to strong GR positivity of myoepithelial and luminal cells
Uterus, ectocervix
Uterus, ectocervix – Significant GR staining of squamous epithelial cells. Staining intensity decreases sligthly towards the surface
Uterus, endocervix
Uterus, endocervix – Moderate GR positivity of epithelial cells
Uterus, endometrium (pregnancy)
Uterus, endometrium (pregnancy) – Moderate GR positivity of decidua and of epithelial cells
Uterus, endometrium (secretion)
Uterus, endometrium (secretion) – Moderate GR positivity of stroma cells while endometrium cells are largely GR negative
Uterus, myometrium
Uterus, myometrium – Strong GR positivity of myometrial cells
Fallopian tube, mucosa
Fallopian tube, mucosa – Strong GR positivity of all epithelial cells
Ovary, stroma
Ovary, stroma – Strong GR positivity of stromal cells
Ovary, follicular cyst
Ovary, follicular cyst – Granulosa cells are largely GR negative
Ovary, corpus luteum
Ovary, corpus luteum – Moderate to strong GR positivity of corpus luteum cells
Placenta, mature, amnion and chorion
Placenta, mature, amnion and chorion – Strong GR positivity of amnion and chorion cells
Placenta, early
Placenta, early – Strong GR staining of trophoblast and stroma cells
Placenta, mature
Placenta, mature – Strong GR staining of stroma cells while trophoblast cells are negative

Muscle, connective & soft tissue

Skeletal muscle
Skeletal muscle – Strong GR positivity of skeletal muscle cells
Aorta, media
Aorta, media – Moderate to strong GR positivity of spindle shaped cells in the media
Heart muscle
Heart muscle – Strong GR positivity of heart muscle cells
Urinary bladder, muscular wall
Urinary bladder, muscular wall – Moderate GR positivity of smooth muscle cells
Appendix, muscular wall
Appendix, muscular wall – Moderate to strong GR positivity of smooth muscle cells
Colon descendens, muscular wall
Colon descendens, muscular wall – Moderate to strong GR positivity of smooth muscle cells

Skin

Skin
Skin – Intense GR positivity of squamous epithelial cells. Staining intensity decreases slightly towards the surface

Bone Marrow & lymphoid tissues

Bone marrow
Bone marrow – Strong GR positivity of almost all hematopoetic cells
Thymus
Thymus – Strong GR positivity of lymphocytic cells. GR staining is only weak in squamous epithelial cells of corpuscles of Hassall‘s
Spleen
Spleen – Strong GR positivity of lymphocytic cells
Lymph node
Lymph node – Strong GR positivity of lymphocytic cells
Tonsil
Tonsil – Strong GR positivity of lymphocytic cells