Cancer Tissues

Glucocorticoid Receptor

Endocrine Tissues

Adrenal gland

Adrenal gland – Adrenocortical adenoma showing only a faint GR staining of tumor cells while stroma cell staining is more intense

Adrenal gland

Adrenal gland – Pheochromocytoma with strong GR staining of tumor cells

Thyroid

Thyroid – Anaplastic carcinoma with strong GR positivity of all tumor cells

Thyroid

Thyroid – Medullary cancer with moderate to strong GR staining of tumor cells

Respiratory system

Lung

Lung – Adenocarcinoma with strong GR positivity of all tumor cells

Proximal digestive tract

Esophagus

Esophagus – Adenocarcinoma with only faint GR staining of a small group of tumor cells while inflammatory cells show strong GR positivity

Esophagus

Esophagus – Squamous cell carcinoma with strong GR staining of all tumor cells

Salivary gland

Salivary gland – Warthin tumor with moderate to strong GR staining of epithelial cells while staining is strong in inflammatory cells

Gastronintestinal tract

Stomach

Stomach – Gastric adenocarcinoma showing a strong GR staining of tumor and stroma cells

Stomach

Stomach – Gastrointestinal stromal tumor (GIST) with strong GR staining of all tumor cells

Stomach

Stomach – GR negative diffuse type gastric adenocarcinoma with intermingled stroma cells showing strong GR positivity

Stomach

Stomach – GR negative gastric adenocarcinoma (diffuse type) with intermingled stroma cells showing strong GR expression

Stomach

Stomach – GR negative gastric adenocarcinoma

Colon

Colon – Colorectal adenocarcinoma with moderate to strong GR positivity of tumor cells while staining is even stronger in stroma cells

Colon

Colon – GR negative colorectal adenocarcinoma. GR staining is retained in stromal cells

Liver, Gallbladder, Pancreas

Liver

Liver – Cholangiocellular carcinoma with strong GR positivity of tumor cells

Liver

Liver – Hepatocellular carcinoma with strong GR immunostaining of tumor cells

Pancreas

Pancreas – Ductal adenocarcinoma with moderate to strong GR staining of tumor cells

Pancreas

Pancreas – GR negative neuroendocrine tumor. GR staining is only seen in stromal cells

Pancreas

Pancreas – Neuroendocrine tumor with strong GR positivity of tumor cells

Kidney, urinary bladder

Kidney

Kidney – Clear cell renal cell carcinoma with strong GR positivity of tumor cells

Kidney

Kidney – GR negative clear cell carcinoma. GR staining is only seen in stromal cells

Kidney

Kidney – Papillary renal cell carcinoma with strong GR staining of tumor cells

Kidney

Kidney – Papillary renal cell carcinoma with strong nuclear but also significant GR staining of tumor cells

Soft tissue

Soft tissue – GR negative rhabdoid tumor. GR staining is only seen in non-neoplastic cells

Urinary bladder

Urinary bladder – GR negative muscle-invasive urothelial carcinoma with mucinous features. GR staining is strong in stromal cells

Urinary bladder

Urinary bladder – Muscle-invasive urothelial carcinoma with strong GR staining of all tumor cells

Male tissues

Prostate

Prostate – Adenocarcinoma (Gleason 3+3=6) with strongly reduced GR staining in tumor cells as compared to adjacent normal epithelial cells

Prostate

Prostate – Adenocarcinoma (Gleason 5+4=9) with strong GR staining of tumor cells

Prostate

Prostate – GR negative adenocarcinoma (Gleason 4+4=8) with strong GR positivity of stromal cells

Prostate

Prostate – GR negative adenocarcinoma (Gleason 4+4=8). GR staining only occurs in stromal cells

Testis

Testis – GR negative embryonal carcinoma. GR staining is retained in stromal cells

Testis

Testis – GR negative seminoma. GR staining only occurs in stromal cells

Testis

Testis – Leydig cell tumor with strong GR immunostaining of tumor cells

Female Tissues

Breast

Breast – GR negative invasive breast cancer of no special type (NST). GR staining is strong in stromal cells

Breast

Breast – GR negative invasive lobular breast cancer exhibiting a distinct GR staining in stromal cells

Uterus

Uterus – Cervical adenocarcinoma with moderate GR staining of tumor cells

Ovary

Ovary – GR negative clear cell carcinoma. GR staining is retained in stromal cells

Ovary

Ovary – GR negative serous high-grade carcinoma showing a strong GR staining of stromal cells

Ovary

Ovary – Serous high-grade carcinoma showing a strong GR immunostaining of all tumor cells

Skin

Skin – Melanoma with strong GR immunostaining of tumor cells

Bone Marrow & lymphoid tissues

Lymph node

Lymph node – Diffuse large B-cell lymphoma with strong nuclear and weak cytoplasmic GR staining of tumor cells

Lymph node

Lymph node – Follicular B-cell lymphoma with strong GR staining of all tumor cells

Lymph node

Lymph node – Hodgkin’s lymphoma with strong GR staining of tumor cells and of reactive inflammatory cells