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Cancer Tissues
HMGB1
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Normal Tissues
Endocrine Tissues
Adrenal gland
Adrenal gland – Adrenocortical adenoma with weak to moderate HMGB1 staining of tumor cells
Adrenal gland
Adrenal gland – Pheochromocytoma lacking HMGB1 staining in tumor cells
Adrenal gland
Adrenal gland – Pheochromocytoma with absence HMGB1 staining in tumor cells
Respiratory system
Lung
Lung – Malignant mesothelioma with only a faint HMGB1 staining of tumor cells
Proximal digestive tract
Oral cavity
Oral cavity – Squamous cell carcinoma lacking HMGB1 staining in tumor cells
Oral cavity
Oral cavity – Squamous cell carcinoma with moderate intensity HMGB1 staining of tumor cells
Oral cavity
Oral cavity – Squamous cell carcinoma with strong HMGB1 immunostaining of tumor cells
Esophagus
Esophagus – Adenocarcinoma showing a strong HMGB1 staining of tumor cells
Esophagus
Esophagus – Squamous cell carcinoma lacking HMGB1 staining in tumor cells
Esophagus
Esophagus – Squamous cell carcinoma with strong HMGB1 staining of tumor cells
Salivary gland
Salivary gland – Warthin tumor with strong HMGB1 staining of tumor and inflammatory cells
Gastronintestinal tract
Stomach
Stomach – Gastric adenocarcinoma (intestinal type) with strong nuclear and moderate cytoplasmic HMGB1 staining of tumor cells
Stomach
Stomach – Gastric adenocarcinoma largely lacking HMGB1 staining in tumor cells
Stomach
Stomach – Gastrointestinal stromal tumor (GIST) lacking HMGB1 staining of tumor cells
Stomach
Stomach – Gastrointestinal stromal tumor (GIST) with moderate to strong HMGB1 immunostaining of tumor cells
Liver, Gallbladder, Pancreas
Liver
Liver – Cholangiocellular carcinoma lacking HMGB1 immunostaining in tumor cells
Liver
Liver – Cholangiocellular carcinoma with moderate to strong HMGB1 staining of tumor cells
Liver
Liver – Hepatocellular carcinoma with moderate to strong HMGB1 staining of tumor cells
Pancreas
Pancreas – Neuroendocrine tumor with strong HMGB1 positivity of tumor cells
Kidney, urinary bladder
Kidney
Kidney – Chromophobe renal cell carcinoma with a complete loss of HMGB1 staining of tumor cells
Kidney
Kidney – Chromophobe renal cell carcinoma with strong HMGB1 immunostaining of all tumor cells
Kidney
Kidney – Clear cell renal cell carcinoma with a complete loss of HMGB1 staining i tumor cells
Kidney
Kidney – Clear cell renal cell carcinoma with strong HMGB1 staining of all tumor cells
Kidney
Kidney – Papillary renal cell carcinoma lacking HMGB1 staining in tumor cells
Kidney
Kidney – Papillary renal cell carcinoma with strong HMGB1 positivity of tumor cells
Urinary bladder
Urinary bladder – Muscle-invasive urothelial carcinoma showing a strong HMGB1 positivity of all tumor cells
Male tissues
Prostate
Prostate – Adenocarcinoma (Gleason 3+3=6) largely lacking HMGB1 staining of tumor cells
Prostate
Prostate – Adenocarcinoma (Gleason 5+5=10) lacking HMGB1 staining in tumor cells
Prostate
Prostate – Adenocarcinoma (Gleason 5+5=10) with strong nuclear and moderate cytoplasmic HMGB1 staining of tumor cells
Prostate
Prostate – Recurrent adenocarcinoma (Gleason 5+5=10) after hormonal therapy now showing a complete loss HMGB1 staining of tumor cells
Testis
Testis – Seminoma lacking HMGB1 immunostaining in tumor cells
Female Tissues
Uterus
Uterus – Leiomyosarcoma with moderate HMGB1 immunostaining of tumor cells
Ovary
Ovary – Clear cell carcinoma showing a complete lack of HMGB1 staining in tumor cells
Ovary
Ovary – Malignant mixed Mullerian tumor exhibiting a strong HMGB1 staining of tumor cells
Bone Marrow & lymphoid tissues
Soft tissue
Soft tissue – Chondrosarcoma largely lacking HMGB1 staining of tumor cells
Lymph node
Lymph node – Angioimmunoblastic T-cell lymphoma with absence of HMGB1 positivity in the tumor cells
