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Normal Tissues

SDHB

Brain

Cerebrum, grey matter
Cerebrum, grey matter – Weak to moderate granular cytoplasmic SDHB staining of neurons and glia cells
Cerebrum, white matter
Cerebrum, white matter – Weak to moderate granular cytoplasmic SDHB staining of glia cells
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer)
Cerebellum, cortex (molecular layer, Purkinje cell layer, granule cell layer) – Rather weak granular cytoplasmic SDHB staining of cells
Cerebellum (white matter)
Cerebellum (white matter) – Weak to moderate granular cytoplasmic SDHB staining of glia cells

Endocrine Tissues

Adrenal gland
Adrenal gland – Strong granular cytoplasmic SDHB staining of epithelial cells
Thyroid gland
Thyroid gland – Weak granular cytoplasmic SDHB staining of epithelial cells
Parathyroid gland
Parathyroid gland – Moderate to strong granular cytoplasmic SDHB staining of epithelial cells. Marked heterogeneity between cells
Pituitary gland, anterior lobe
Pituitary gland, anterior lobe – Strong granular cytoplasmic SDHB staining of epithelial cells
Pituitary gland, posterior lobe
Pituitary gland, posterior lobe – Weak granular cytoplasmic SDHB staining of pituicytes

Respiratory system

Lung

Proximal digestive tract

Tonsil, surface epithelium
Tonsil, surface epithelium – Weak to moderate granular cytoplasmic SDHB staining of squamous epithelial cells and of lymphocytes
Parotid gland
Parotid gland – Granular cytoplasmic SDHB staining is strong in excretory ducts and only faint in glandular cells

Gastronintestinal tract

Stomach, antrum
Stomach, antrum – A granular cytoplasmic SDHB staining occurs in all cells but it is strongest in stomach glands
Stomach, corpus
Stomach, corpus – A granular cytoplasmic SDHB staining occurs in all cells but is strongest in glands, especially in parietal cells
Duodenum, Brunner gland
Duodenum, Brunner gland – Weak to moderate granular cytoplasmic SDHB staining of glandular cells

Liver, Gallbladder, Pancreas

Liver
Liver – Substantial granular cytoplasmic SDHB staining of cells, especially in hepatocytes
Pancreas
Pancreas – A granular cytoplasmic SDHB staining occurs in all epithelial cells. It is weakest in islet cells and strongest in some small excretory ducts

Kidney, urinary bladder

Kidney, cortex
Kidney, cortex – Intense granular cytoplasmic SDHB staining of tubuli while staining is weak in glomeruli
Kidney, medulla
Kidney, medulla – Granular cytoplasmic SDHB staining of variable intensity of a subset of collecting ducts
Urinary bladder, urothelium
Urinary bladder, urothelium – Weak to moderate granular cytoplasmic SDHB staining of urothelial cells (all layers)

Male tissues

Epididymis
Epididymis – Weak granular cytoplasmic SDHB staining in epithelial cells of the corpus
Epididymis
Epididymis – Weak to moderate granular cytoplasmic SDHB staining, predominately in the sub-apical compartment, in epithelial cells of the cauda
Prostate
Prostate – Rather weak granular cytoplasmic SDHB staining – somewhat stronger in epithelial than in stromal cells
Seminal vesicle
Seminal vesicle – Strong granular cytoplasmic SDHB staining in most epithelial cells
Testis
Testis – Granular cytoplasmic SDHB staining is strongest in maturing germ cells

Female Tissues

Breast
Breast – Moderate granular cytoplasmic SDHB staining of epithelial cells
Uterus, ectocervix
Uterus, ectocervix – Weak granular cytoplasmic SDHB staining, largely limited to suprabasal squamous epithelial cells
Uterus, endocervix
Uterus, endocervix – Weak granular cytoplasmic SDHB staining of epithelial cells
Uterus, endometrium (proliferation)
Uterus, endometrium (proliferation) – Weak granular cytoplasmic SDHB staining of epithelial cells
Uterus, endometrium (pregnancy)
Uterus, endometrium (pregnancy) – Weak to moderate granular cytoplasmic SDHB staining of epithelial and decidua cells
Uterus, endometrium (secretion)
Uterus, endometrium (secretion) – Moderate granular cytoplasmic SDHB staining of epithelial and stromal cells
Uterus, endometrium (secretion)
Uterus, endometrium (secretion) – Weak granular cytoplasmic SDHB staining of epithelial and stromal cells
Uterus, myometrium
Uterus, myometrium – Weak granular cytoplasmic SDHB staining of muscle cells
Fallopian tube, mucosa
Fallopian tube, mucosa – Weak to moderate granular cytoplasmic SDHB staining of epithelial cells
Ovary, stroma
Ovary, stroma – Moderate granular cytoplasmic SDHB staining of stromal cells
Ovary, corpus luteum
Ovary, corpus luteum – Moderate granular cytoplasmic SDHB staining of corpus luteum cells
Placenta (Amnion and chorion)
Placenta (Amnion and chorion) – Weak to moderate granular cytoplasmic SDHB staining of amnion and chorion cells
Placenta, early
Placenta, early – Weak granular cytoplasmic SDHB staining of throphoblast cells
Placenta, mature
Placenta, mature – Weak granular cytoplasmic SDHB staining of throphoblast cells

Muscle, connective & soft tissue

Skeletal muscle
Skeletal muscle – Weak to moderate granular cytoplasmic SDHB staining
Aorta, media
Heart muscle
Heart muscle – Strong granular cytoplasmic SDHB staining
Urinary bladder, muscular wall
Urinary bladder, muscular wall – Moderate granular cytoplasmic SDHB staining of smooth muscle cells
Appendix, muscular wall
Appendix, muscular wall – Weak granular cytoplasmic SDHB staining of smooth muscle cells
Colon descendens, mucosa
Colon descendens, mucosa – At least a moderate granular cytoplasmic SDHB staining of all cells, predominantly in the epithelium
Colon descendens, muscular wall
Colon descendens, muscular wall – Granular cytoplasmic SDHB staining of smooth muscle cells is only faint. SDHB staining is markedly more intense in ganglion cells

Skin

Skin
Skin – Moderate granular cytoplasmic SDHB staining, predominantly of basal and suprabasal squamous epithelial cells
Skin
Skin – Weak granular cytoplasmic SDHB staining, predominantly of basal and suprabasal squamous epithelial cells

Bone Marrow & lymphoid tissues

Bone marrow
Bone marrow – Granular cytoplasmic SDHB staining is only faint, if at all visible
Thymus
Thymus – Weak to moderate granular cytoplasmic SDHB staining of lymphocytes
Spleen
Spleen – Faint granular cytoplasmic SDHB staining of a fraction of inflammatory cells
Lymph node
Lymph node – Weak to moderate granular cytoplasmic SDHB staining of lymphocytes
Tonsil
Tonsil – Weak to moderate granular cytoplasmic SDHB staining of lymphocytes