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Cancer Tissues
SDHB
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Normal Tissues
Endocrine Tissues
Adrenal gland
Adrenal gland – Adrenocortical adenoma with moderate SDHB immunostaining of tumor cells
Adrenal gland
Adrenal gland – Adrenocortical carcinoma with intense SDHB staining of all tumor cells
Adrenal gland
Adrenal gland – Pheochromocytoma with moderate SDHB immunostaining of tumor cells
Thyroid
Thyroid – Medullary cancer with moderate SDHB positivity of tumor cells
Thyroid
Thyroid – Papillary cancer with moderate SDHB immunostaining of tumor cells
Proximal digestive tract
Esophagus
Esophagus – Adenocarcinoma with strong SDHB staining of tumor cells
Salivary gland
Salivary gland – Warthin tumor with intensive SDHB immunostaining of epithelial tumor cells
Gastronintestinal tract
Stomach
Stomach – Gastric adenocarcinoma (diffuse type) with strong SDHB positivity of tumor cells
Stomach
Stomach – Gastrointestinal stromal tumor (GIST) with strong SDHB immunostaining of tumor cells
Stomach
Stomach – Gastrointestinal stromal tumor (GIST) with strong SDHB staining of tumor cells (2)
Stomach
Stomach – Gastrointestinal stromal tumor (GIST) with strong SDHB staining of tumor cells
Colon
Colon – Colorectal adenocarcinoma with strong SDHB staining of tumor cells.jpeg
Liver, Gallbladder, Pancreas
Liver
Liver – Cholangiocellular carcinoma with strong SDHB immunostaining of tumor cells
Liver
Liver – Hepatocellular carcinoma with intense SDHB staining of tumor cells
Pancreas
Pancreas – Acinar cell carcinoma showing SDHB staining of variable intensity in tumor cells
Pancreas
Pancreas – Ductal adenocarcinoma with intense SDHB tumor cell positivity
Pancreas
Pancreas – Neuroendocrine tumor showing moderate to strong SDHB positivity of tumor cells
Kidney, urinary bladder
Kidney
Kidney – Absence of granular SDHB staining in tumor cells of an SDH deficient renal cell carcinoma
Kidney
Kidney – Chromophobe renal cell carcinoma with strong SDHB labeling of tumor cells
Kidney
Kidney – Clear cell renal cell carcinoma exhibiting a strong SDHB immunostaining of tumor cells
Kidney
Kidney – Clear cell renal cell carcinoma showing moderate SDHB immunostaining of tumor cells
Kidney
Kidney – Papillary renal cell carcinoma with moderate to strong SDHB staining of tumor cells
Kidney
Kidney – SDHB mutated renal cell carcinoma lacking granular SDHB staining of tumor cells
Urinary bladder
Urinary bladder – Muscle-invasive urothelial carcinoma showing weak to moderate SDHB immunostaining of tumor cells
Male tissues
Prostate
Prostate – Adenocarcinoma (Gleason 3+3=6) with moderate intensity SDHB staining of tumor cells
Prostate
Prostate – Adenocarcinoma (Gleason 4+4=8) showing marked SDHB positivity of tumor cells
Testis
Testis – Leydig cell tumor with intense SDHB staining of tumor cells
Testis
Testis – Seminoma with intensepositivity SDHB immunostaining of tumor cells
Female Tissues
Breast
Breast – Invasive breast cancer of no special type (NST) with strong SDHB immunostaining of tumor cells
Uterus
Uterus – Leiomyosarcoma with moderate SDHB staining of tumor cells
Soft tissue
Soft tissue – Paraganglioma with complete loss of granular SDHB staining of tumor cells. Intense STHB staining of inflammatory and stroma cells
Soft tissue
Soft tissue – SDH deficient paraganglioma lacking granular SDHB staining in all tumor cells. Stroma cells are SDHB positive
Bone Marrow & lymphoid tissues
Lymph node
Lymph node – Diffuse large B-cell lymphoma with strong SDHB staining of tumor cells
Lymph node
Lymph node – Hodgkin’s lymphoma with strong SDHB positivity of tumor associated inflammatory cells. Tumor cells are also positive
