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Cancer Tissues

TYMS

Endocrine Tissues

Adrenal gland
Adrenal gland – Pheochromocytoma with faint TYMS staining of only very few tumor cells
Adrenal gland
Adrenal gland – TYMS negative adrenocortical adenoma
Thyroid
Thyroid – Anaplastic carcinoma with strong TYMS immunostaining of most tumor cells
Thyroid
Thyroid – TYMS negative medullary carcinoma
Thyroid
Thyroid – TYMS negative papillary carcinoma

Respiratory system

Lung
Lung – Adenocarcinoma with strong TYMS immunostaining of about 50_ of tumor cells
Lung
Lung – Large cell neuroendocrine carcinoma with strong TYMS staining of a large fraction of tumor cells
Lung
Lung – Squamous cell carcinoma with strong TYMS staining of most tumor cells of the peripheral cell layers
Lung
Lung – TYMS negative malignant mesothelioma (epitheloid)

Proximal digestive tract

Esophagus
Esophagus – Adenocarcinoma with moderate to strong TYMS immunostaining of most tumor cells
Esophagus
Esophagus – Squamous cell carcinoma with strong TYMS positivity of most tumor cells
Salivary gland
Salivary gland – TYMS negative Warthin tumor. TYMS staining is seen in some lymphoid cells

Gastronintestinal tract

Stomach
Stomach – Gastric adenocarcinoma (diffuse type) with weak to moderate TYMS staining of a fraction of tumor cells
Stomach
Stomach – Gastric adenocarcinoma (intestinal type) with weak to strong TYMS staining of about half of the tumor cells
Stomach
Stomach – Gastrointestinal stromal tumor (GIST) with strong TYMS staining of a scattered tumor cells
Stomach
Stomach – TYMS negative gastrointestinal stromal tumor (GIST)
Colon
Colon – Colorectal adenocarcinoma with strong TYMS staining of more than 50_ of tumor cells
Colon
Colon – TYMS negative colorectal adenocarcinoma. TYMS staining is only seen in some inflammatory cells

Liver, Gallbladder, Pancreas

Liver
Liver – Cholangiocellular carcinoma with faint TYMS staining of only very few tumor cells
Liver
Liver – Hepatocellular carcinoma with highly variable, weak to strong TYMS staining of _60_ of tumor cells
Gallbladder
Gallbladder – Neuroendocrine carcinoma with strong TYMS positivity of most tumor cells
Pancreas
Pancreas – Neuroendocrine tumor with weak TYMS staining of few tumor cells. TYMS staining is also seen in some inflammatory cells
Pancreas
Pancreas – TYMS negative ductal adenocarcinoma
Pancreas
Pancreas – TYMS negative neuroendocrine tumor. TYMS staining only occurs in some inflammatory cells

Kidney, urinary bladder

Kidney
Kidney – TYMS negative clear cell carcinoma
Kidney
Kidney – TYMS negative papillary renal cell carcinoma
Urinary bladder
Urinary bladder – Muscle-invasive urothelial carcinoma with moderate to strong TYMS staining of most tumor cells
Urinary bladder
Urinary bladder – Muscle-invasive urothelial carcinoma with strong TYMS immunostaining of a subset of tumor cells
Urinary bladder
Urinary bladder – Sarkomatoid carcinoma with moderate to strong TYMS staining of all tumor cells
Urinary bladder
Urinary bladder – TYMS negative muscle-invasive urothelial carcinoma

Male tissues

Prostate
Prostate – Adenocarcinoma (Gleason 5+5=10) with strong TYMS staining of tumor cells
Prostate
Prostate – TYMS negative adenocarcinoma (Gleason 3+3=6)
Testis
Testis – Embryonal carcinoma with moderate TYMS positivity of most tumor cells
Testis
Testis – TYMS negative seminoma. TYMS staining is only seen in some inflammatory cells

Female Tissues

Breast
Breast – Invasive breast cancer of no special type (NST) with weak TYMS staining of few tumor cells
Breast
Breast – TYMS negative invasive lobular breast cancer
Ovary
Ovary – Serous high-grade carcinoma with moderate to strong TYMS staining of a subset of tumor cells
Ovary
Ovary – Serous high-grade carcinoma with weak to moderate TYMS staining of a fraction of tumor cells

Muscle, connective & soft tissue

Penis
Penis – Squamous cell carcinoma with moderate to strong TYMS immunostaining of almost all tumor cells
Penis
Penis – Squamous cell carcinoma with strong TYMS staining of of most cells of the peripheral tumor cell layers. TYMS staining also occurs in some inflammatory cells

Skin

Skin
Skin – Malignant melanoma with strong TYMS positivity of more than half of the tumor cells
Skin
Skin – TYMS negative basal cell carcinoma

Bone Marrow & lymphoid tissues

Lymph node
Lymph node – Diffuse large B-cell lymphoma with moderate to strong TYMS staining of a subset of tumor cells
Lymph node
Lymph node – Diffuse large B-cell lymphoma with variable, weak to strong TYMS staining of almost all tumor cells
Lymph node
Lymph node – Hodgkin’s lymphoma with variable, weak to strong TYMS staining of a subset of tumor cells. A fraction of non-neoplastic cells are also TYMS positive
Lymph node
Lymph node – Hodgkin’s lymphoma with weak to moderate TYMS immunostaining of tumor cells. TYMS staining is also seen in many inflammatory cells
Lymph node
Lymph node – TYMS negative B-CLL. TYMS positivity appears to be limited to a small subset of non-neoplastic lymphocytic cells
Lymph node
Lymph node – TYMS negative tumor cells in a Hodgkin’s lymphoma. TYMS positivity is only seen in a small subset of non-neoplastic cells