Cancer Tissues

Insulin

Endocrine Tissues

Adrenal gland

Adrenal gland – Insulin negative adrenocortical adenoma

Adrenal gland

Adrenal gland – Insulin negative pheochromocytoma

Thyroid

Thyroid – Insulin negative medullary carcinoma

Thyroid

Thyroid – Insulin negative papillary carcinoma

Respiratory system

Lung

Lung – Insulin negative adenocarcinoma

Lung

Lung – Insulin negative squamous cell carcinoma

Proximal digestive tract

Esophagus

Esophagus – Insulin negative adenocarcinoma

Esophagus

Esophagus – Insulin negative squamous cell carcinoma

Salivary gland

Salivary gland – Insulin negative Warthin tumor

Gastronintestinal tract

Stomach

Stomach – Insulin negative gastric adenocarcinoma

Stomach

Stomach – Insulin negative gastrointestinal stromal tumor (GIST)

Colon

Colon – Insulin negative colorectal adenocarcinoma

Liver, Gallbladder, Pancreas

Liver

Liver – Insulin negative cholangiocellular carcinoma

Liver

Liver – Insulin negative hepatocellular carcinoma

Pancreas

Pancreas – Insulin negative adenocarcinoma of the papilla Vaterii

Pancreas

Pancreas – Neuroendocrine tumor (insulinoma) with moderate to strong Insulin staining of tumor cells

Pancreas

Pancreas – Neuroendocrine tumor (insulinoma) with strong Insulin positivity of the majority of tumor cells

Pancreas

Pancreas – Neuroendocrine tumor (insulinoma) with strong Insulin staining of all tumor cells. Due to the abundance of insulin in the tissue, staining also occurs in the stroma (contamination artifact)

Kidney, urinary bladder

Kidney

Kidney – Insulin negative clear cell carcinoma

Kidney

Kidney – Insulin negative papillary renal cell carcinoma

Urinary bladder

Urinary bladder – Insulin negative muscle-invasive urothelial carcinoma

Male tissues

Prostate

Prostate – Insulin negative adenocarcinoma (Gleason 3+3=6)

Testis

Testis – Insulin negative Leydig cell tumor

Testis

Testis – Insulin negative seminoma

Female Tissues

Uterus, cervix

Uterus, cervix – Insulin negative adenocarcinoma

Ovary

Ovary – Insulin negative serous high-grade carcinoma

Bone Marrow & lymphoid tissues

Lymph node

Lymph node – Insulin negative diffuse large B-cell lymphoma